The NC ASSISTments Replication Study began in the 2017-18 school year and aimed to replicate the findings from a prior study conducted in Maine. That study found that the students of 7th-grade mathematics teachers who used ASSISTments for homework scored significantly higher on the Terra Nova mathematics exam than the students of teachers who did not use ASSISTments. Unfortunately, the COVID-19 pandemic forced North Carolina’s schools to move to all-remote instruction in March 2020 and the End-of-Grade exams were canceled, which made the replication study impossible to complete. This forced a change in the ASSISTments study and a re-evaluation of what researchers could learn about the use of ASSISTments in schools in North Carolina. Using surveys and interviews, researchers at the Friday Institute for Educational Innovation conducted a case study of teachers’ use of ASSISTments in in-person instruction and in remote instruction, both during the NC ASSISTments Replication Study and outside of the study.